Research advances in the relationship between nonalcoholic fatty liver disease and chronic kidney disease
10.3969/j.issn.1001-5256.2022.11.030
- VernacularTitle:非酒精性脂肪性肝病与慢性肾病关系的研究进展
- Author:
Mengru YANG
1
;
Rui HAN
1
Author Information
1. Second Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Reviews
- Keywords:
Non-alcoholic Fatty Liver Disease;
Nephrosis;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(11):2586-2591
- CountryChina
- Language:Chinese
-
Abstract:
More and more studies have shown that nonalcoholic fatty liver disease (NAFLD) is closely associated with chronic kidney disease (CKD). Although the causal relationship has not been clarified, the mechanisms, such as metabolic disorders, diet-intestinal microbiota axis disorders, oxidative stress, platelet activation, and genetic and epigenetic regulation, play an important role in the disease interaction network. This article reviews the evidence for the association between NAFLD and CKD and the potential mechanisms under which NAFLD and its related factors may increase the risk of CKD, and moreover, it proposes related patient management recommendations and treatment strategies.
