Influencing factors for HBeAg seroconversion in patients with chronic hepatitis B
10.3969/j.issn.1001-5256.2022.11.029
- VernacularTitle:慢性乙型肝炎患者HBeAg血清学转换影响因素的研究进展
- Author:
Ziyang GU
1
;
Anhui WANG
2
;
Wenchang HE
1
;
Jiayu LI
1
;
Changxing HUANG
1
Author Information
1. Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China
2. Department of Epidemiology, School of Military Preventive Medicine, Air Force Medical University, Xi'an 710032, China
- Publication Type:Reviews
- Keywords:
Hepatitis B, Chronic;
Hepatitis B e Antigens;
Influencing Factors
- From:
Journal of Clinical Hepatology
2022;38(11):2581-2585
- CountryChina
- Language:Chinese
-
Abstract:
HBeAg seroconversion refers to the disappearance of HBeAg and the appearance of anti-HBe in chronic hepatitis B (CHB) patients with positive HBeAg in the past. HBeAg seroconversion marks the reductions in viral replication, immune tolerance, and liver inflammation and is an important monitoring indicator for evaluating disease conditions and the effect of CHB antiviral therapy, and it also indicates the endpoint of satisfactory treatment. Exploring the influencing factors for HBeAg seroconversion is of great significance to the selection of treatment regimens and the prognostic evaluation of CHB patients. This article mainly elaborates on the association of HBV with HBeAg seroconversion in CHB patients from the aspects of virological factors, host genetic factors, drug factors, and immunological factors.
