Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis
10.3969/j.issn.1001-5256.2022.11.013
- VernacularTitle:益生菌对轻微型肝性脑病患者显性肝性脑病发生率影响的Meta分析
- Author:
Yuhao YAO
1
,
2
;
Jiaxin ZHANG
2
,
3
;
Xiao XIA
4
;
Shun ZHU
2
;
Xiaoke LI
2
,
3
;
Yong'an YE
2
,
3
Author Information
1. First School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3. Liver Diseases Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100700, China
4. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
- Publication Type:Original Articles_Liver Fibrosis and Liver Cirrhosis
- Keywords:
Hepatic Encephalopathy;
Probiotics;
Meta-Analysis
- From:
Journal of Clinical Hepatology
2022;38(11):2505-2509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review and analyze the effect of probiotics in preventing the overt hepatic encephalopathy (OHE) in patients with minimal hepatic encephalopathy (MHE). Methods Studies about this subject were searched in PubMed, Web of Science, Cochrane Library, Chinese journal full-text database (CNKI), WanFang data knowledge service platform (WanFang Data) from their establishment to November 2021. Meta-analysis was performed using RevMan 5.4. Description analysis was used for data that could not be pooled. The relative risk ( RR ) and 95% confidence interval ( CI ) were used to present pooled data. Results Six RCT studies with a total of 404 patients were included in this meta-analysis. The results showed probiotics users had a significant reduction of the OHE incidence, as compared with the controls ( RR =0.46, 95% CI : 0.26 - 0.81; P =0.007), but an increase in the reversal MHE rate ( RR =4.94, 95% CI : 2.82-8.66; P < 0.000 01). Conclusion This finding demonstrated that probiotics were able to effectively reduce the OHE incidence and improve the reversal MHE rate in the patients with MHE. This study could provide novel evidence for probiotics treatment of MHE.
