A new isocoumarin from a starfish-associated fungus Aspergillus sp. WXF1904
10.16438/j.0513-4870.2022-0577
- VernacularTitle:海星共附生真菌Aspergillus sp. WXF1904中一个新的异香豆素
- Author:
Ling-ling WANG
1
;
Da GUAN
1
,
2
;
Xiao-fang WANG
3
;
Xiao-yan PANG
4
;
Yong-hong LIU
4
,
5
;
Xiu-ping LIN
4
,
5
Author Information
1. Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China
2. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
3. Marine Environmental Engineering Center, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
4. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
5. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China
- Publication Type:Research Article
- Keywords:
starfish-associated fungus;
italic>Aspergillus sp. WXF1904;
secondary metabolite;
isocoumarin;
acetylcholinesterase inhibitory activity
- From:
Acta Pharmaceutica Sinica
2022;57(11):3356-3360
- CountryChina
- Language:Chinese
-
Abstract:
A fungal strain WXF1904, was isolated from a starfish sample corrected in the South China Sea. According to its internal transcribed spacer (ITS) analysis, the strain was identified as a member of the genus Aspergillus and designated as Aspergillus sp. WXF1904. One new isocoumarin containing halogennamed 6-chloro-5,7-dihydroxy-3,8-dimethylisocoumarin (1), along with six known compounds pilobolusate (2), p-hydroxybenzaldehyde (3), methyl orsellinate (4), catechol (5), vanillic acid (6), and wasabidienone E (7), were isolated from the cultures of Aspergillus sp. WXF1904 by silica gel column chromatography, ODS gel column chromatography, and high performance liquid chromatography (HPLC). Their structures were elucidated by high resolution mass spectrometry (HR-MS), nuclear magnetic resonance (NMR) as well as literature comparison. The new compound 5-chloro-6,7-dihydroxy-3,8-dimethylisocoumarin and compound 2 showed weak acetylcholinesterase inhibitory activity.
