Problems and challenges of genetically modified pig to non-human primate kidney xenotransplantation
10.3969/j.issn.1674-7445.2022.06.018
- VernacularTitle:基因修饰猪-非人灵长类动物异种肾移植面临的问题及挑战
- Author:
Hongtao JIANG
1
;
Tao LI
;
Songzhe HE
;
Yifan YU
;
Yunhao BAI
;
Xiaojie MA
;
Yi WANG
Author Information
1. Department of Transplantation, the Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China
- Publication Type:Research Article
- Keywords:
Kidney xenotransplantation;
Genetically modified pig;
Non-human primate;
Rejection;
Coagulation disorder;
Inflammation;
Immunosuppressant;
Cross-infection
- From:
Organ Transplantation
2022;13(6):810-
- CountryChina
- Language:Chinese
-
Abstract:
Xenotransplantation is one of the potential approaches to mitigate the shortage of donor kidneys. With the progress of gene modification techniques and the development of immunosuppressant, significant progress has been made in the preclinical research of genetically modified pig to non-human primate (NHP) xenotransplantation. The longest survival time of recipients exceeds 500 d. However, the number of recipients surviving for over 1 year is extremely low, and most recipients die within postoperative 1-2 months. Therefore, several problems remain to be clarified and resolved. In this article, rejection, refractory coagulation dysfunction, persistent inflammation, the selection of immunosuppressant, the selection of clinical recipients and the risk of cross-infection in genetically modified pig to NHP xenotransplantation were reviewed, and current problems and potential solutions of genetically modified pig to NHP xenotransplantation were summarized, aiming to provide reference for promoting xenotransplantation in clinical settings.
