Correlation between tacrolimus and diabetes mellitus after kidney transplantation: a single center study
10.3969/j.issn.1674-7445.2022.06.013
- VernacularTitle:他克莫司与肾移植术后糖尿病相关性的单中心研究
- Author:
Ziyu WANG
1
;
Chen DONG
;
Hongyang WANG
;
Qinghai WANG
;
Chen GUO
;
Tao HUANG
;
Jianlei JI
;
Yanwei CAO
;
Zhen DONG
Author Information
1. Affiliated Hospital of Qingdao University, Qingdao 266000, China
- Publication Type:Research Article
- Keywords:
Tacrolimus;
Kidney transplantation;
Diabetes mellitus;
Risk factor;
Trough concentration;
Fasting blood glucose;
Postprandial blood glucose;
Animal model
- From:
Organ Transplantation
2022;13(6):776-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the major risk factors of post transplantation diabetes mellitus (PTDM) and analyze the correlation between tacrolimus and PTDM after kidney transplantation. Methods Clinical data of 123 kidney transplant recipients were collected. All recipients were divided into the PTDM group (n=19) and non-PTDM group (n=104). Clinical data of all recipients in two groups were analyzed. The risk factors of PTDM were analyzed by binary logistic regression. Twenty-four mice were evenly divided into the control group (normal saline), low-dose tacrolimus (0.1 mg/kg), medium-dose tacrolimus (0.75 mg/kg) and high-dose tacrolimus groups (1.5 mg/kg). The solutions were given twice a day. The effect of tacrolimus on blood glucose metabolism in mice was evaluated. Results The incidence of PTDM was 15.4% (19/123) within 1 year after kidney transplantation. Age≥48 years old and the trough concentration of tacrolimus≥9 ng/mL within 3 months after kidney transplantation were the risk factors for PTDM after kidney transplantation (both P < 0.05). The fasting blood glucose levels of mice after administration in the low-, medium- and high-dose tacrolimus groups were significantly lower than those before administration (all P < 0.05) in a dose-independent manner (P=0.750). In the low-, medium- and high-dose tacrolimus groups, the postprandial blood glucose levels of mice after administration were significantly higher than those before administration (all P < 0.05) in a dose-dependent manner (P=0.012). Conclusions Tacrolimus is intimately correlated with the incidence of PTDM after kidney transplantation. Age≥48 years old and the trough concentration of tacrolimus ≥9 ng/mL within 3 months after kidney transplantation are the independent risk factors of PTDM. Tacrolimus affects the postprandial blood glucose levels of mice in a dose-dependent manner.
