Design, synthesis and anti-platelet aggregation activity of paeonol oxime derivatives
10.11665/j.issn.1000-5048.20220504
- VernacularTitle:丹皮酚肟衍生物的设计、合成及抗血小板聚集活性
- Author:
Weiguo DAI
1
;
Hongzhou TAN
;
Hongxia GU
;
Bing HE
;
Liqin HE
;
Peng HUANG
Author Information
1. 安徽中医药大学药学院
- Publication Type:Journal Article
- Keywords:
peaonol oxime derivatives;
synthesis;
aqueous solubility;
anti-platelet aggregation
- From:
Journal of China Pharmaceutical University
2022;53(5):535-541
- CountryChina
- Language:Chinese
-
Abstract:
In order to afford new antiplatelet agents with higher potency, a series of paeonol oxime derivatives (4a-4y) were designed and synthesized from paeonol.Their structures were confirmed by HRMS, 1H NMR spectra.The anti-platelet aggregation activity of the target compounds was evaluated.The results revealed that most of them had moderate to good anti-platelet aggregation activity.Among them, compound 4h and 4j were the most potent on adenosine diphosphate (ADP)-induced platelet aggregation and collagen-induced platelet aggregation. Furthermore, the target compound 4h not only showed strong antiplatelet aggregation activity, but also exhibited good water-solubility and drug-like properties, which can be used as a new antiplatelet active compound for further research.
