Research progress of T cell anti-tumor function regulated by endoplasmic reticulum stress
10.11665/j.issn.1000-5048.20220502
- VernacularTitle:内质网应激对T细胞抗肿瘤功能调控的研究进展
- Author:
Zhenghao WANG
1
;
Yafeng GAO
;
Lianjun ZHANG
;
Chang LIU
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
endoplasmic reticulum stress;
T cell;
anti-tumor immunity;
progress
- From:
Journal of China Pharmaceutical University
2022;53(5):518-524
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum (ER) stress is involved in the development and progression of tumors.In recent years, great attention has been paid to the study of the interplay of ER stress and T cell differentiation and functionality.Intense ER stress in the tumor-infiltrating T cells exacerbates T cell exhaustion and impairs T cell anti-tumor immunity.Therefore, a variety of ER stress inhibitors have been developed and utilized to alleviate T cell exhaustion, which improves T cell function in tumor microenvironment.Furthermore, the downregulation of several circadian clock genes like Per1 and Per2 also aggravates T cell exhaustion, and the key downstream effector molecules in ER stress regulate the transcription of Per family, thus enhancing the T cell function.In the present manuscript, we particularly summarize how ER stress impacts the anti-tumor immunity of T cells, and further discuss potential strategies for improving tumor immunotherapy via targeting ER stress.
