TCM Intervention on Pyroptosis Based on Yin-Yang Theory： A Review
10.13422/j.cnki.syfjx.20222297
- VernacularTitle:基于阴阳理论研究中医药干预细胞焦亡的研究进展
- Author:
Qinyuan DU
1
;
Congcong QIN
1
;
Yimin ZHANG
1
;
Meiling SUN
1
;
Xijun MA
1
;
Cheng LI
1
;
Sichao ZHANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine， Jinan 250355， China
- Publication Type:Journal Article
- Keywords:
cell pyroptosis;
traditional Chinese medicine;
Yin-Yang theory;
Yin-Yang regulation;
cysteine aspartate-specific protease （Caspase）;
gasdermin family
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):276-282
- CountryChina
- Language:Chinese
-
Abstract:
Cell pyroptosis is a programmed death of inflammatory cells. Many members of the gasdermin family （the effector protein family that forms pores） participate in the pathological process of a variety of diseases， such as cancer， myocardial ischemia， renal injury， and osteoarthritis， mainly by activating cysteine aspartate-specific protease （Caspase） for polymerization and shear. Cell pyroptosis has bidirectional regulation. Induction of pyroptosis can promote cell clearance under pathological conditions （such as cancer and tumor cells）， but long-term induction of pyroptosis can lead to abnormal lipid and related vitamin metabolism in vivo. Regulating the balance between cell pyroptosis and proliferation is an important target for traditional Chinese medicine （TCM） treatment of diseases. The Yin-Yang theory runs through the whole process of TCM diagnosis and treatment， which is used to explain the physiological and pathological changes of human body and guide the theory， diagnosis and treatment of diseases and health care. The balance between cell proliferation and pyroptosis is essentially the embodiment of Yin-Yang balance at the cellular level， and the theory of Yin-Yang spontaneous harmonization dominates the balance. TCM intervention on cell pyroptosis is mainly reflected in promoting and inhibiting cell pyroptosis， which has the same significance as Yin-Yang regulation. Based on this theory， this paper revealed the relationship between TCM inhibiting and promoting cell pyroptosis through the Yin-Yang theory， to provide theoretical support for the modernization of the Yin-Yang theory and new goals for the diagnosis and treatment of diseases.
