Chinese Medicine Regulates PI3K/Akt Signaling Pathway to Treat Ischemic Stroke： A Review
10.13422/j.cnki.syfjx.20221205
- VernacularTitle:PI3K/Akt信号通路与缺血性脑卒中的关系及中药干预的研究进展
- Author:
Jianyun ZHANG
1
;
Jingwen LI
1
;
Lihong ZHANG
1
;
Yiying WANG
1
;
Jinjin MEI
1
;
Jian GUO
2
;
Ruiqing LI
1
Author Information
1. School of Rehabilitation Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Journal Article
- Keywords:
phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway;
Chinese medicine;
ischemic stroke;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):265-275
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke， an acute cerebrovascular disease caused by sudden arterial occlusion， is characterized by high morbidity， high mortality， and high disability rate. It is a major cause of the occurrence and death of neurologic diseases in the world. The phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway is a classic pathway for cellular metabolism， growth， and apoptosis. In recent years， Chinese medicine has played an important role in the treatment of ischemic stroke because of the small side effects and wide range of targets and has received extensive attention. The compound prescriptions and extracts of Chinese medicines can treat diseases via multiple targets and pathways. Researchers have extensively studied the occurrence and development of ischemic stroke and the pathophysiological mechanism of drug intervention in the treatment of ischemic stroke and have demonstrated that PI3K/Akt signaling pathway plays a key role in this process. The PI3K/Akt signaling pathway is involved in the occurrence and development of ischemic stroke by regulating pathophysiological processes such as inflammation， oxidative stress response， apoptosis， and autophagy， in which Chinese medicines play a regulatory role. This paper reviews the relationship between PI3K/Akt signaling pathway and ischemic stroke and the mechanism of Chinese medicine in treating ischemic stroke by regulating PI3K/Akt signaling pathway， aiming to provide a new theoretical basis for the clinical treatment of stroke.
