Prevention and Treatment of Type 2 Diabetes Mellitus with Traditional Chinese Medicine Based on Inflammatory Signaling Pathways： A Review
10.13422/j.cnki.syfjx.20222295
- VernacularTitle:中医药基于炎症信号通路调控防治2型糖尿病的研究进展
- Author:
Wanrong GUO
1
;
Wei LIU
1
;
Liji HUANG
2
;
Shaofeng XIE
3
Author Information
1. The Third Clinical Medical College of Nanjing University of Chinese Medicine，Nanjing 210028，China
2. Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，China
3. Integrated Traditional Chinese and Western Medicine Hospital affiliated to Nanjing University of Chinese Medicine，Nanjing 210028，China
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
inflammatory response;
inflammatory signaling pathway;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):249-256
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus （T2DM），as a chronic disease with an increasing prevalence，has greatly affected the quality of life of patients， and aroused widespread concern in society. Previous studies have shown that inflammation is closely related to the occurrence and development of T2DM. The role of inflammatory response and its signaling pathway in the pathogenesis of T2DM has become a research hotspot，and the intervention of inflammatory response to control the progression of T2DM has become a new approach for treatment. With the deepening in the research field of traditional Chinese medicine （TCM），the generation of inflammation is attributed to turbid phlegm and blood stasis， whose mutual transformation results in the impairment of body functions. However，the monomers and compounds of Chinese medicine in the treatment of T2DM based on inflammatory signaling pathways are advantageous in multiple targets，multiple pathways， and few side effects，which can significantly relieve the symptoms of T2DM. In recent years，there has been an increasing number of studies on TCM intervention in T2DM. The present article elaborated the understanding of the relationship between T2DM and inflammation in TCM and the seven signaling pathways related to the regulation of inflammation in T2DM by TCM， including nuclear transcription factor-κB （NF-κB） signaling pathway，mitogen-activated protein kinase （MAPK）-dependent signaling pathway，phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway，protein kinase C （PKC） signaling pathway，adenosine 5′-monophosphate （AMP）-activated kinase （AMPK） signaling pathway，Wnt signaling pathway，and transforming growth factor-β （TGF-β） signaling pathway.
