Application and Thinking of Platform Method in Construction of Animal Model of Human Disease
10.13422/j.cnki.syfjx.20222293
- VernacularTitle:平台水环境法构建人类疾病动物模型的应用与思考
- Author:
Ruochong WANG
1
;
Ning DAI
1
;
Ruting LI
1
;
Shuo SUN
1
;
Yan JIA
1
;
Jie LI
1
;
Feng LI
1
;
Weiyue ZHANG
2
Author Information
1. School of Traditional Chinese Medicine，Beijing University of Chinese Medicine，Beijing 102488，China
2. School of Nursing，Beijing University of Chinese Medicine，Beijing 102488，China
- Publication Type:Journal Article
- Keywords:
platform technique;
modified multiple platform method （MMPM）;
traditional Chinese medicine （TCM） disease and syndrome combination;
fatigue;
sleep deprivation;
depression;
anxiety;
mania
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):205-213
- CountryChina
- Language:Chinese
-
Abstract:
Platform method is a modeling method that forces experimental animals to stand on the platforms for a long time without rest by taking advantage of the rodent's fear of water. The application time and node of platform method in model construction can be adjusted according to the needs of different types of animal models. At present， the research hotspot of platform method focuses on constructing animal models of sleep deprivation， anxiety and depression and other mental diseases as well as fatigue. In recent years， with the development of the modernization of traditional Chinese medicine （TCM）， this method has been gradually applied to the study of TCM syndrome model and TCM disease and syndrome combination model with "heart"，"liver" and "spleen" as the centers. Due to the extensive application of platform method and the diversity of modeling diseases， there is still a lack of systematic discussion on this method as the core. This paper systematically summarized the research in China and abroad and explored the application of platform method in animal models of human diseases from three dimensions： its development process， current application and problems and future development. In addition， through the analysis of the research hotspots on sleep deprivation， mental diseases， fatigue， TCM syndrome model and TCM disease and syndrome combination model，the ideas and specific applications of platform method in construction of various animal models were discussed. This paper was expected to provide reference for researchers and promote further exploration and research of this modeling method.
