Influence of Inflammation on Tumor and Intervention of Chinese Medicine： Based on "Inflammation-tumor Transformation"
10.13422/j.cnki.syfjx.20221424
- VernacularTitle:基于“炎-癌转化”探讨炎症对肿瘤的影响及中医药干预作用
- Author:
Mengfan PENG
1
;
Ming LI
1
;
Jinxin MIAO
1
;
Shuo TIAN
1
;
Yuanxin ZHANG
1
;
Chenhui LI
1
;
Mingsan MIAO
1
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Journal Article
- Keywords:
tumor;
inflammatory response;
Chinese medicine;
clinical diagnosis;
prognosis evaluation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):196-204
- CountryChina
- Language:Chinese
-
Abstract:
With high incidence and lethality rate and certain disability rate， tumor has become a major global public health threat. It has been verified that the occurrence and development of tumor are resulted from the synergy of environment， heredity， and gene mutation， involving the abnormal activation or inhibition of a variety of related pathways such as oxidative stress， inflammation， autophagy， and mesenchymal transition of cells. Among them， the excessive activation of inflammatory signaling pathway is one of the main mechanisms of carcinogenesis and tumor progression， which enhances the proliferation， chemoradiotherapy resistance， invasion， and metastasis of cancer cells. At the moment， the correlation between long-term chronic uncontrollable inflammation and "inflammation-cancer transformation" has been widely recognized. Therefore， it is of great significance for the prevention and treatment， diagnosis， and prognosis evaluation of tumor to clarify the role of inflammation in the incidence of tumor. Blockers or activators have been developed to target the corresponding inflammatory pathways. However， tumor is accompanied by the abnormality of multiple inflammatory pathways， especially the advanced tumor with metastasis of cancer cells， and thus the efficacy of single pathway-targeting agents is non-ideal. Chinese medicine， featuring multiple components and multiple targets， can remarkably control the inflammatory response， delay tumor progression， enhance the sensitivity of tumor cells to radiotherapy and chemotherapy， and reduce postoperative infection and the adverse reactions caused by radiotherapy and chemotherapy， thereby exerting the anti-cancer effect. Nevertheless， a few reports on the anti-tumor effect of Chinese medicine from the perspective of inflammation are available. Therefore， this paper mainly expounds the influence of inflammation on the occurrence and development of tumor and summarizes the research on the intervention of tumor by Chinese medicine through inflammatory pathway， which is expected to provide a new mindset for the prevention and treatment of tumor.
