Clinical Evolution Law of Syndrome Elements in Different Stages of Chronic Obstructive Pulmonary Disease Based on Complex Network Method
10.13422/j.cnki.syfjx.20220916
- VernacularTitle:基于复杂网络方法的慢性阻塞性肺疾病不同分期证候要素演变规律临床调查
- Author:
Weike LI
1
;
Zhiwan WANG
1
Author Information
1. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-construction by Henan province & Education Ministry of PR China，Henan Key Laboratory of Chinese Medicine for Respiratory Disease，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
complex network;
syndrome elements;
evolution law
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):143-148
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the dynamic evolution law of syndrome elements in different stages of chronic obstructive pulmonary disease （COPD）. MethodThe clinical questionnaire of COPD was formulated，and the clinical data of 303 patients with COPD in the acute exacerbation stage，risk window stage，and stable stage in the First Affiliated Hospital of Henan University of Chinese Medicine from June 2019 to December 2020 were dynamically collected. The Clinical Investigation and Research Database on the Evolution of Syndrome Elements of COPD was established，with syndrome elements as nodes and complex relationships between syndrome elements and syndrome elements in different stages as edges. With the help of Pycharm （JetBrains PyCharm Edition 2018.2.3） development tool，python programming was used to preprocess the data and perform complex network modeling. The complex network of different stages of COPD was constructed to analyze the evolution law of syndrome factors in different stages. ResultA total of 303 patients with COPD were included and finished. Eleven syndrome elements were extracted in the acute exacerbation stage，10 syndrome elements were extracted in the risk window stage，and 8 syndrome elements were extracted in the stable stage. According to the complex network centrality and edge weight of disease syndrome elements，it was found that the core nodes of disease syndrome elements in the network from the acute exacerbation stage to the stable stage were phlegm，heat，and Qi deficiency，Qi deficiency，phlegm，and dampness，and Qi deficiency，Yin deficiency，and blood stasis. ConclusionFrom the acute exacerbation stage to the stable stage，the disease syndrome elements change from excess to deficiency，and phlegm heat gradually changes into phlegm dampness，and gradually weakens or disappears. Qi deficiency runs through the whole process of the disease and turns into both qi and yin deficiency with blood stasis.
