Modified Bufei Huangqitang Combined with Acupuncture in Treatment of Moderate-to-severe Allergic Rhinitis due to Deficiency and Cold in Lung and Kidney
10.13422/j.cnki.syfjx.20222192
- VernacularTitle:补肺黄芪汤加减联合针刺治疗中重度变应性鼻炎肺肾虚寒证的临床疗效
- Author:
Rui WEI
1
;
Lulu CHEN
1
;
Jingbo LI
1
;
Junjie WANG
1
;
Jitang CAI
1
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
acupuncture;
Bufei Huangqitang;
allergic rhinitis;
deficiency and cold in lung and kidney syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(22):131-136
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of modified Bufei Huangqitang combined with acupuncture on moderate-to-severe allergic rhinitis due to deficiency and cold in lung and kidney. MethodA total of 130 patients were divided into a control group （65 cases） and an observation group （65 cases） according to a random number table. The patients in the control group were treated with cetirizine hydrochloride tablets （10 mg per night） combined with mometasone furoate nasal spray （one press on each side，once a day），and those in the observation group were treated with acupuncture （once a day） combined with modified Bufei Huangqitang（1/2 dose each time，twice a day） for 15 days. The rhinoconjunctivitis quality of life questionnaire （RQLQ），total nasal symptom score （TNSS），nasal airway resistance （NAR），and traditional Chinese medicine （TCM） syndrome score of allergic rhinitis with deficiency and cold in lung and kidney syndrome were observed before and after treatment in two groups. The neuropeptide Y （NPY），vasoactive intestinal peptide （VIP），substance P （SP） in nasal secretions， and immune inflammatory markers ［eosinophil （EOS），eotaxin （EOT），immunoglobulin E （IgE），and interleukin-33 （IL-33）］ in serum were detected. Adverse reactions of the two groups were observed during the study period. ResultThe total effective rate was 96.9% （63/65） in the observation group， higher than 81.5% （53/65） in the control group （χ2=7.943，P<0.05）. After treatment，the RQLQ，TNSS，NAR， and TCM syndrome scores in the observation group were lower than those in the control group （P<0.05）. The nasal secretions NPY in the observation group was higher than that in the control group （P<0.05），while VIP and SP in the observation group were lower than those in the control group （P<0.05）. The serum EOS，IgE， and IL-33 in the observation group were lower than those in the control group （P<0.05）， while the serum EOT in the observation group was higher than those in the control group （P<0.05）. Adverse reactions occurred in two cases in the control group and one case in the observation group. The incidence of adverse reactions had no statistical significance between the two groups. ConclusionAcupuncture combined with modified Bufei huangqitang can significantly relieve the clinical symptoms of moderate-to-severe allergic rhinitis due to deficiency and cold in lung and kidney and improve the serum immune inflammatory markers， with good safety.
