A Case of Cutaneous Manifestations Associated With Hydroxyurea Therapy.
- Author:
Soo Jung JANG
1
;
Yong Joo MOON
;
Yong Ho CHOI
;
Jung Hwan KIM
;
Jee Youn WON
Author Information
1. Department of Dermatology, Presbyterian Medical Center, Chonju, Korea. drsuejin@hanmail.net
- Publication Type:Case Report
- Keywords:
Hydroxyurea;
Cutaneous manifestations
- MeSH:
Aged;
Alopecia;
Deoxyribonucleotides;
DNA;
Humans;
Hydroxyurea*;
Hyperpigmentation;
Keratoderma, Palmoplantar;
Ribonucleotides;
Skin Ulcer
- From:Korean Journal of Dermatology
2003;41(7):965-967
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hydroxyurea is an antitumor agent that has attained an important role in the management of myeloproliferative syndromes. Its mechanism of action is not fully understood, but it appears to affect DNA synthesis and genetic control of cell replication by inhibiting the conversion of ribonucleotides in deoxyribonucleotides. Cutaneous side effects such as xerosis, hyperpigmentation, nail changes, skin ulceration, alopecia, and palmoplantar keratoderma may occur, especially with long-term treatment. We report a case of 65-year-old chronic myelogenous leukemia(CML) patient showing various cutaneous manifestations after receiving long-term hydroxyurea therapy.
