Effect of Chinese Medicine on Signaling Pathways Related to Hepatocellular Carcinoma and Its Potential Mechanism： A Review
10.13422/j.cnki.syfjx.20221427
- VernacularTitle:中药对肝细胞癌相关信号通路的影响及潜在机制
- Author:
Peirong QIU
1
;
Zeshan CHEN
1
;
Wenlin ZHU
1
;
Peichun PENG
1
;
Jitian WU
1
;
Yulian LI
1
;
Xin DENG
1
Author Information
1. Guangxi University of Chinese Medicine， Nanning 530001， China
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
signaling pathway;
mechanism;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(23):264-272
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma （HCC）， an insidious malignant tumor with high incidence and lethality， poses a major threat to physical and mental health of human beings. The pathological mechanism needs to be further studied. Surgery， radiotherapy， chemotherapy， and targeted drugs are effective but induce many adverse reactions. Traditional Chinese medicine （TCM） has unique advantages and abundant clinical experience in the treatment of HCC. There has been an explosion of research on the pathways， targets， and mechanism of TCM against HCC from the perspective of molecular biology. According to previous research， Chinese medicinals or compound Chinese medicine prescriptions， directly or indirectly prevent the occurrence and progression of HCC through multiple pathways and targets， which is closely related to the pathophysiological processes such as cell proliferation， metastasis， apoptosis， autophagy， inflammatory response， and immune response. This paper summarizes and analyzes research on the action pathways and mechanisms of Chinese medicine against HCC. Specifically， isoliquiritigenin， dendrobium candidum and Yexiazhu compound Ⅱ regulate phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway to inhibit the growth， proliferation and metastasis of tumor cells. Toad venom and dioscorea zingiberensis induce and enhance HCC autophagy by modulating mammalian target of rapamycin （mTOR） signaling pathway. Myricetin， asparagus， and Biejiajian Wan regulate mitogen-activated protein kinase （MAPK） signaling pathway to promote HCC cell cycle arrest， inhibit angiogenesis， and induce apoptosis. Polygonum odoratum， tetragonum， and plantainoside modulate nuclear factor-kappa B （NF-κB） to inhibit inflammatory response and HCC metastasis and reduce drug resistance. Quercetin and erigeron breviscapus control the Janus kinase 2/signal transducer and activator of transcription 3 （JAK2/STAT3） signaling pathway to suppress epithelial-mesenchymal transition （EMT） and remodel cytoskeleton. This paper is expected to lay a theoretical basis for the in-depth research on and clinical application of Chinese medicine in the treatment of HCC.
