Effect of Activating Blood Therapy of Traditional Chinese Medicine on Inflammatory Factors in Patients with Acute Cerebral Infarction： A Review
10.13422/j.cnki.syfjx.20222036
- VernacularTitle:中医药活血治疗对急性脑梗死患者炎症因子影响研究进展
- Author:
Yi ZHANG
1
;
Hong ZHANG
1
;
Lin GAO
2
;
Yinqi SHUAI
2
;
Xiaoqing LIU
2
;
Hainan JIANG
2
;
Xiaoyun ZHANG
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610072，China
2. Chengdu University of TCM，Chengdu 610075，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
activating blood therapy;
acute cerebral infarction;
inflammatory factors;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(23):250-263
- CountryChina
- Language:Chinese
-
Abstract:
Acute cerebral infarction （ACI）， also known as ischemic stroke， is a disease with a high disability rate， which brings heavy burdens to society and families. Its pathogenesis is related to many factors， of which the inflammatory theory is one of the important mechanisms. In the early stage of ACI， microglia are activated， and the inflammatory mediators， such as interleukins and tumor necrosis factor-α （TNF-α）， released by them induce vascular endothelial cells to express adhesion molecules. The circulating leukocytes （neutrophils， monocyte-macrophages， etc.） are promoted to roll and adhere to the injured vascular endothelium， migrate and cross the blood-brain barrier， penetrate and infiltrate the brain parenchyma， and further expand the local inflammatory response by releasing a variety of proinflammatory mediators， thus exacerbating the tissue injury at the injury site and ischemic penumbra. Traditional Chinese medicine （TCM） has advantages in treating the disease. TCM believes that the occurrence of stroke is related to blood stasis caused by various reasons， which block the brain vessel. This article reviewed the research progress on the effect of activating blood therapy on inflammatory factors in patients with ACI in recent years and discussed its regulation of inflammatory factors in ACI such as interleukin-1 （IL-1）， interleukin-6 （IL-6）， interleukin-8 （IL-8）， interleukin-10 （IL-10）， TNF-α， C reactive protein （CRP）， and monocyte chemotactic protein-1 （MCP-1）， hoping to elucidate the scientific connotation of TCM treatment of ACI and lay the foundation for further research.
