Huangqintang in Treatment of Ulcerative Colitis： A Review
10.13422/j.cnki.syfjx.20222298
- VernacularTitle:黄芩汤治疗溃疡性结肠炎的研究现状
- Author:
Haoxian SUN
1
;
Guixiang SUN
1
;
Ying ZHU
2
Author Information
1. Hunan University of Chinese Medicine，Changsha 410208，China
2. The First Hospital of Hunan University of Chinese Medicine，Changsha 410007，China
- Publication Type:Review
- Keywords:
Huangqintang;
ulcerative colitis;
research progress;
mechanism;
clinical application
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(23):219-227
- CountryChina
- Language:Chinese
-
Abstract:
Huangqintang comes from Treatise on Cold Damage Diseases （《伤寒论》） and is regarded as the traditional prescription for treating dysentery. It is composed of four herbs： Radix Scutellariae， Radix Paeoniae Alba， Fructus Jujubae and Radix Glycyrrhizae， with the effect of clearing heat and stopping dysentery， and is a classic prescription for clinical treatment of ulcerative colitis （UC）. Both experimental research and clinical practice show Huangqintang has the characteristics of multiple pathways and multiple targets in treating UC. At present， research on the mechanism of Huangqintang in the treatment of UC mainly focuses on reducing intestinal inflammation， repairing epithelial cell barrier， improving microflora disorder， maintaining immune balance， relieving oxidative stress， regulating mitochondrial autophagy， and inhibiting cell pyroptosis and ferroptosis. In clinical application， Huangqintang and its modified prescription combined with conventional western medicine have a clear effect on UC， which can significantly alleviate abdominal pain， diarrhea， purulent bloody stool and other symptoms， effectively control the condition and improve the quality of life of patients， with few adverse reactions and high safety. However， the experimental methods and research programs of Huangqintang in treating UC need to be further improved， and the related mechanisms need to be further studied. Through retrieval and sorting of relevant literature， this paper systematically summarized and comprehensively analyzed the mechanism and clinical research results of Huangqintang in treating UC in recent years， and proposed suggestions on the shortcomings in order to provide theoretical and data support for the further application of Huangqintang. This had practical guiding significance for interpreting the connotation of Huangqintang and clinical scientific application.
