Effects of Aortic Valve Stenosis on the Flow Field Characteristics of Ascending Aortic Aneurysm
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0314
- VernacularTitle:主动脉瓣狭窄对升主动脉瘤流场特征的影响
- Author:
Hao-tian LI
1
;
Lei LÜ
1
;
Song-ran YANG
2
;
Ping HUA
1
Author Information
1. Department of Cardiovascular Surgery， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510120， China
2. Department of Biotherapy Center， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510120， China
- Publication Type:Journal Article
- Keywords:
aortic valve stenosis;
ascending aortic aneurysm;
computational fluid dynamics;
hemodynamic index;
propensity score matching
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(3):462-470
- CountryChina
- Language:Chinese
-
Abstract:
【Objection】 To evaluate the effects of aortic valve stenosis on the flow field characteristics of ascending aortic aneurysm by computational fluid dynamics and hemodynamic indexes. MethodsA total of 63 patients aged 18 or over with ascending aortic dilation or aneurysm were retrospectively recruited from Sun Yat-sen Memorial Hospital of Sun Yat-sen University and assigned to aortic valve stenosis （AS） or none aortic valve stenosis （NAS） group. Propensity score matching analysis and ascending aortic division based on centerline were performed to compare the hemodynamic indexes ［pressure， shear stress rate （SSR）， wall shear stress （WSS）， time average shear stress rate （TASSR）， time average wall shear stress （TAWSS）］. ResultsThere were significant differences in SSR （191.70 ［117.22~248.78］ s-1 vs. 93.23 ［68.59~145.35］ s-1， Z = 2.167， P = 0.030） and WSS （2.87 ［1.88~4.00］ Pa vs. 1.20 ［1.04~2.18］ Pa， Z = 2.233， P = 0.026） between AS group and NAS group. The differences were mainly found in the proximal and lesser curvature of ascending aorta （P < 0.05）. There was no statistical significance in pressure， TASSR or TAWSS. ConclusionsAortic valve stenosis alters the hemodynamics in ascending aortic dilation or aneurysms， which increases tangential component force （e.g. SSR， WSS） but has no significant effects on perpendicular component force （e.g. pressure）.
