Prognostic and Immunological Role of ABHD5： a Pan-Cancer Analysis
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0308
- VernacularTitle:脂代谢相关基因ABHD5在泛癌中的表达模式及其与预后和免疫浸润的相关性分析
- Author:
Yu⁃tao CHEN
1
;
Yang YANG
1
;
Gan XIA
1
;
Miao-hong XU
1
;
Ji-zhao CAO
1
;
Jia-yin LU
1
;
Yan ZOU
2
;
Xia YANG
1
Author Information
1. Department of Biochemistry and Molecular Biology， Zhongshan School of Medicine， Sun Yat⁃sen University， Guangzhou 510080， China
2. Guangzhou Women and Children’s Medical Center， Guangzhou 510623， China
- Publication Type:Journal Article
- Keywords:
ABHD5;
pan-cancer;
differential expression;
neutrophil infiltration;
immune checkpoints;
histone demethylation
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(3):400-411
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the ABHD5 expression in pan-cancer and its correlations with the main clinical stages， prognosis and immune cell infiltration. MethodsGTEx， TCGA， TIMER2.0， CPTAC databases， immunohistochemistry and western blot were used to analyze the expression levels of ABHD5 in different cancer tissues and adjacent tissues as well as correlations between ABHD5 expression and the main clinical stages. Kaplan-Meier Plotter， Oncolnc and R2 databases were used to explore the prognostic value of ABHD5. The relationship between ABHD5 and immune cell infiltration was analyzed by TCGA and TIMER2.0 databases. STRING and GEPIA databases were used to detect ABHD5-binding proteins and co-expression genes， which were then analyzed by GO and KEGG. ResultsThe mRNA and protein expression levels of ABHD5 were lower in cancer tissues than those in normal tissues in multiple cancer types， but higher in few cancer types. High-level expression of ABHD5 was related to better prognosis in 8 cancer types and related to worse prognosis in 2. ABHD5 expression levels were positively correlated with immune cell infiltration in 9 cancer types， and were the same with neutrophil infiltration and expression of immune checkpoints in pan-cancer. Enrichment analysis showed that ABHD5 was related to histone demethylation. ConclusionPossibly used as a potential prognostic predictor in pan-cancer， ABHD5 was also correlated with neutrophil infiltration， expression of immune checkpoints and histone demethylation.
