Regulation of Dietary Cichoric Acid in Allergic Asthmatic Mice In Vivo
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0305
- VernacularTitle:膳食菊苣酸对过敏性哮喘小鼠的体内调节作用
- Author:
Qin LI
1
;
Yun-qin SHEN
1
;
Xing-yue GUO
2
;
Yi-xuan XU
1
;
Ling-jie LI
1
;
Yin-fan WU
3
;
Yan YANG
1
;
Yanqiu CHEN
4
Author Information
1. School of Public Health （Shenzhen）， Sun Yat-sen University， Shenzhen 518000， China
2. Guangdong Provincial Key Laboratory of Food， Nutrition and Health， School of Public Health， Sun Yat-sen University （Guangzhou）， Guangzhou 510080， China
3. Department of Clinical Nutrition， Shanghai Fourth People's Hospital Affiliated to Tongji University， Shanghai 200434， China
4. Department of Otolaryngology， Guangzhou Women and Children Medical Center， Guangzhou 510623， China.
- Publication Type:Journal Article
- Keywords:
cichoric acid;
allergic asthma;
inflammation;
eosinophil;
T cell
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(3):373-380
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the in vivo effect of dietary cichoric acid supplement in allergic asthmatic mice. MethodsSixteen five-week-old female BALB/c mice were randomly divided into four groups： normal group （control）， allergic asthmatic group （OVA）， dietary cichoric acid group （OVA + CA）， and drug-control group （OVA + DEX）. Ovalbumin was applied to induce allergic asthmatic murine model. During the whole experiment， mice were fed with feed that contained 400 mg/kg cichoric acid or no cichoric acid. The body weight changes and nasal symptoms were observed and recorded during the experiment. After sacrifice， the pulmonary histopathological changes， the number and proportion of peripheral inflammatory cells， and the percentages of subsets of helper T cell （Th） and cytotoxic T cell （Tc） in lung tissues were measured. ResultsCompared with OVA group， the mice in OVA + CA group showed alleviated body weight loss and nasal symptoms （P<0.05）， decreased number of eosinophils and eosinophil/lymphocyte ratio in peripheral blood （P<0.05）， alleviated inflammatory infiltration and goblet cell proliferation of lungs tissues （P<0.05）， decreased percentages of Th2， Th17 ， Tc2， Tc17 in lungs （P<0.001）， while the percentages of Th1 and Tc1 did not change （P>0.05）. ConclusionsDietary cichoric acid supplementation could improve in vivo inflammation in allergic asthmatic mice.
