Predictive Effect of High Density Lipoprotein to C-reactive Protein Ratio on Progression of Chronic Kidney Disease in Non-Dialysis Patient
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0217
- VernacularTitle:高密度脂蛋白与 C反应蛋白比值对非透析慢性肾脏病进展的预测作用
- Author:
Lei-le TANG
1
;
Xing-hua GUO
2
;
Shao-min LI
3
;
Pei-jia LIU
4
;
Jia FANG
3
;
Xun LIU
3
Author Information
1. Department of Cardiovascular Medicine
2. Department of Rheumatology
3. Department of Nephrology
4. Department of Emergency Medicine； The Third Affliated Hospital of Sun Yat-sen University， Guangzhou 510635， China
- Publication Type:Journal Article
- Keywords:
high-density lipoprotein;
C-reactive protein;
ratio;
chronic kidney disease;
predictive effect
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(2):305-315
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the predictive effect of high density lipoprotein （HDL） to C-reactive protein （CRP） ratio （HDL/CRP） on the progression of chronic kidney disease （CKD） in non-dialysis patients. MethodsNon-dialysis chronic kidney disease patients with at least two sets of follow-up data from the Third Affiliated Hospital of Sun Yat-sen University （Tian-he and Ling-nan districts）from 2015 to 2019 were enrolled. The baseline demographic characteristics and biochemical examination results were collected from the electronic medical record system. The patients were grouped according to the quantile of Ln（HDL/CRP）. The demographic and biochemical data were compared among groups by one-way ANOVA for normal distribution continuous variables， Kruskal-Wallis rank-sum test for non-normal distribution continuous variables， and Chi-square analysis for categorical variables. The relationship between HDL/CRP and baseline eGFR was investigated by correlation analysis， univariate and multivariate linear regression analysis. The Cox survival analysis were used to investigate the predictive effect of Ln（HDL/CRP） on renal deterioration events. ResultsTotally 9 142 patients with CKD were enrolled， and 439 patients were included in the end. There were 100 patients （22.8%） with chronic glomerulonephritis， 145 patients （33%） with diabetic nephropathy， 40 patients （9.1%） with hypertensive nephropathy， and 154 patients （35.1%） with other causes. According to Ln（HDL/CRP） quartile， group Quartile4 had a lower incidence of renal deterioration than the other three groups （11% vs. 21.1% to 21.8%） and had the highest baseline eGFR level. From Quartile1 to quartile 4 groups， age， Hba1c and APOA1 levels decreased gradually. The prevalence of chronic heart failure， BMI， hemoglobin， albumin， TC， LDL， TG， APOB100 levels were different among groups. Through correlation analysis， Ln （HDL/CRP） were positively correlated with baseline eGFR（r=0.162， P=0.001）. After adjusting for a variety of factors by Cox regression analysis， Ln （HDL/CRP） could be included in the final equation when defined deterioration of renal function as end point ［HR=0.79， 95%CI （0.69， 0.91）， P=0.001］. ConclusionHDL/CRP can reflect the severity of chronic kidney disease， and the ratio of HDL and CRP can predict the progression of chronic kidney disease in non-dialysis patient.
