Clinical Characteristics of 67 Cases of Brucellosis
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0216
- VernacularTitle:布鲁菌病67例临床特征
- Author:
Guo-fen ZENG
1
;
Jiang-feng ZHUANG
1
;
Liang GAO
2
;
Kun-yu SHEN
1
;
Yang ZHANG
1
;
Gui-hua SU
2
;
Zhi-liang GAO
3
;
Xin SHU
3
Author Information
1. Department of Infectious Diseases， The Affiliated Kashi Hospital， Sun Yat-sen University， Kashi 844000， China// Department of Infectious Diseases， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China// Department of Infectious Diseases， The First People’s Hospital of Kashi Prefecture， Kashi 844000， China
2. The First People’s Hospital of Kashi Prefecture， Kashi 844000， China
3. Department of Infectious Diseases， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China
- Publication Type:Journal Article
- Keywords:
Brucellosis;
clinical characteristics
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(2):297-304
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the clinical characteristics of brucellosis patients from two tertiary hospitals in epidemic and non-epidemic areas. MethodsThe clinical data of 67 brucellosis patients hospitalized in The Affiliated Kashi Hospital of Sun Yat-sen University （Kashi， 53） and The Third Affiliated Hospital of Sun Yat-sen University （Guangzhou， 14） from January 2019 to December 2019 were retrospectively reviewed， including demographic data， medical history， symptoms， signs， laboratory tests and treatment， and the differences between the two groups were compared. ResultsThere were 23 patients in Kashi and 11 patients in Guangzhou with definite epidemiological history， respectively （P = 0.019）. Fever， fatigue and arthralgia were the most common symptoms of brucellosis. In addition to anorexia， the onset symptoms of patients in the two hospitals were roughly the same. The incidence of fever， muscle pain and fever peak was similar， but the symptoms of hyperhidrosis， fatigue， arthralgia and rash in Kashi were more common in Guangzhou. There were cases of hepatosplenomegaly in both hospitals， but there was no obvious superficial lymphedema. Complications occurred in 39（73.6%） and 11（78.6%） patients in Kashi and Guangzhou， respectively， with no statistical difference （P =0.971）， and hepatitis and bone damage were the most common. The incidence of spondylitis （P =0.042） and neurodegenerative brucellosis （P =0.041） in Guangzhou was higher than that in Kashi， and there was no significant difference in other complications. Of the patients in Kashi， 7.5 % were treated with single antibiotics， and 59.7 % were with dual therapy， which were higher than those in Guangzhou （0， 50.0 %）. The proportion of the triple scheme in Guangzhou was higher than that of Kashi （50.0 % vs. 11.3 %）. ConclusionsThe clinical characteristics of brucellosis in different regions are generally similar， but there are some differences in epidemiological history， symptoms， complications and treatment options. The characteristics of local cases should be concerned in clinical practice to reduce misdiagnosis of brucellosis.
