The Brain Structure Volume Estimation Based on Synthetic MRI in Healthy Children and Youth
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0213
- VernacularTitle:基于集成磁共振成像的正常儿童及青年人脑体积测量
- Author:
Yan DAI
1
;
Ying-qian CHEN
1
;
Shu SU
1
;
Long QIAN
2
;
Liu-hui WU
1
;
Hong-yu ZHANG
3
;
Miao FAN
1
;
Zhi-yun YANG
1
Author Information
1. Department of Radiology , The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080,China
2. MR Research,GE Healthcare,Beijing100000, China
3. Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080,China
- Publication Type:Journal Article
- Keywords:
MRI;
gray matter;
white matter;
children;
youth
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(2):268-275
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the consistency of the brain structure volume estimation based on Synthetic MRI （SyMRI） and T1-FSPGR images in healthy children and youths. MethodsWe prospectively collected the brain SyMRI and T1-FSPGR images of 38 healthy children with age range of 6~13 years old and 30 healthy youths with age range of 22~26 years old. The Sythetic MR software and FreeSurfer software were used to measure the total gray matter volume （GMV）， total white matter volume （WMV）， brain parenchyma volume （BPV） and intracranial volume （ICV） based on SyMRI and T1-FSPGR images respectively. Paired t test， Pearson’s correlation analysis and interclass correlation coefficient （ICC） were used to evaluate the association between SyMRI and T1 derived measurements. ResultsThe volumes estimated by two methods in two groups showed differences in paired t test （P＜0.05）. Nevertheless， both in children and youths， the measurements of GMV， WMV， BPV and ICV all showed noticeable correlation and consistency between the two brain volume estimation methods ［r values are 0.691， 10.577， 0.938， 0.796 in children group and 0.657， 0.623， 0.933， 0.881 in adult group， P＜0.001； ICC95%CIs are 0.816 （0.647， 0.905）， 0.732 （0.484， 0.861）， 0.968 （0.938， 0.983） and 0.880 （0.770， 0.938］ in children group and 0.751 （0.476， 0.881）， 0.760 （0.496， 0.886）， 0.962 （0.920， 0.982）， and 0.936 （0.866， 0.970）in youth group］. ConclusionsThe brain segmentation and volume estimation based on SyMRI can acquire the measurements which have statistical difference but powerful association with that acquired from T1-FSPGR images， which suggests this new method have a good prospect for clinical use and scientific research.
