Association of Late-life Marital Status with Mild Cognitive Impairment and Dementia in Old Age
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0208
- VernacularTitle:老年人婚姻状况与轻度认知障碍及痴呆相关性的横断面研究
- Author:
Ping-ting YAN
1
;
LIU-DAN
1
;
Gui-rong CHENG
1
;
Chong-qing SHI
1
;
HUANG-JING
2
;
ZENG-YAN
1
Author Information
1. Wuhan University of Science and Technology // Brain Science Research Institute, Wuhan 430065, China
2. Wuhan Puren Hospital, Wuhan 430081, China
- Publication Type:Journal Article
- Keywords:
community dwelling old adults;
marital status;
mild cognitive impairment;
dementia;
cohort study
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(2):229-237
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between marital status and the prevalence of mild cognitive impairment (MCI) and dementia in the community dwelling old adults, so as to provide sociological data basis for the prevention and control of cognitive impairment. MethodsPeople aged 65 and above in urban and rural areas of Hubei Province were selected by cluster random sampling, and face-to-face interviews were conducted in community health service centers to complete general investigation and neuropsychological evaluation, as well as clinical physical examination and laboratory examination. The diagnostic expert panels, including two neuroscientists and two neuropsychologists with specialized knowledge of dementia, diagnosed MCI and dementia according to Petersen's MCI standard and Chinese Diagnostic guidelines for dementia and Cognitive impairment. Multivariate Logistic regression was used to analyze the correlation between marital status and MCI and dementia in different age groups. ResultsDuring 2018~2020, 8 221 people completed the full neurocognitive assessment and clinical physical examination, with an average age of (71.96±5.895) years, and 1 953 people, accounting for 23.75% of the total number, were without spouses. The crude prevalence of MCI and dementia in HMACS were 25.98%, 95%CI (24.99%, 26.98%) and 7.24%, 95%CI (6.68%,7.80%), respectively in total participants. After standardization for age and sex using data from the 2010 population census in Hubei Province, the prevalence of MCI and dementia were 26.28% and 6.98%.The prevalence of MCI and dementia in non-spouse [28.07%, 95%CI (26.08%, 30.06%);12.45%, 95%CI (10.99%, 13.91%)] was significantly higher than that in spouse [22.85%, 95%CI(21.81%, 23.89%; 5.62%, 95%CI (5.05%, 6.19%)]. Multivariable logistic regression model showed that the rates of MCI and dementia for married men aged 65~69 [P=0.028, OR=0.639,95%CI(0.429, 0.952)] and above 80 years [P=0.004,OR=0.460, 95%CI (0.269, 0.785)] were significantly lower than those of widowed men. However, there was no statistical difference between the presence or absence of spouses and the prevalence of MCI and dementia in older women. ConclusionsThe prevalence of MCI and dementia is higher in older adults without spouses. Especially for men aged 65~69 and 80 and above, having spouses is important to protect cognitive function.