The Role and Mechanism of Incretins in the Pathogenesis of PCOS
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0421
- VernacularTitle:肠促胰素在PCOS中的作用和机制
- Author:
Meng-ru PAN
1
;
Lin LI
1
Author Information
1. Reproductive Center， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510120， China
- Publication Type:Review
- Keywords:
incretin;
glucagon-like peptide-1 （GLP-1）;
glucose-dependent insulinotropic peptide （GIP）;
hypothalamic-pituitary-ovarian （HPO） axis;
polycystic ovary syndrome （PCOS）
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(4):685-690
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between gut microbiota and disease has become one of the hotspots in recent years. The gut-brain axis may be involved in the pathogenesis of metabolic diseases such as obesity， diabetes and polycystic ovary syndrome （PCOS）， yet the mechanism of gut-brain axis in neuroencrine regulation is still unclear and the gut microbiota as a target to influence hypothalamic-pituitary-ovarian （HPO） axis remains uncertain. Recent reports indicate that enteroendocrine hormones may play a role. Incretins， including glucagon like peptide-1 （GLP-1） and glucose-dependent insulinotropic peptide （GIP）， could promote insulin release and reduce serum glucose level. While the research on incretins and HPO axis is still in its infancy， and the effects of incretins on PCOS has not yet been clarified. This review focuses on the possible role and mechanism of incretins in the pathogenesis of PCOS.
