Early-Life Nutrition Intervention Influences Pubertal Development in Female Rats
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0506
- VernacularTitle:生命早期营养干预对雌性大鼠青春发育的影响
- Author:
Dan-chun CHEN
1
;
Ben-yu TANG
1
;
Shun-ye ZHU
1
Author Information
1. Department of Pediatrics， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510632， China
- Publication Type:Journal Article
- Keywords:
nutrition intervention;
female rats;
pubertal development;
small-for-gestational-age （SGA）;
precocious puberty
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(5):730-737
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the influence of early-life nutrition intervention on pubertal development in female rats. MethodsFifty-eight neonatal female rats born small for gestational age （SGA） by using maternal food restriction were randomly divided into postnatal over-nutrition group （Group IS， n=28） and postnatal normal diet group （Group IC， n=30）. Another 58 neonatal female rats born appropriate for gestational age （AGA） were divided into postnatal over-nutrition group （Group CS， n=28） and postnatal normal diet group （Group CC， n=30）. Then we observed and measured the vaginal opening （VO）， sex hormone levels， organ coefficients of uterus and ovary， and numbers of corpora lutea at various stages of each group. ResultsThe VO in Group IS and Group CS was accelerated than that in Group IC and Group CC. The levels of luteinizing hormone （LH） on postnatal day 35 in Group IS and Group CS were higher than that of Group CC. The levels of estradiol and LH on postnatal day 35 were higher than those on postnatal day 21 in Group IS， Group CS and Group CC. The organ coefficients of uterus and ovary on postnatal day 35 were higher than those on postnatal day 21 in each group. The numbers of corpora lutea on postnatal day 35 and day 45 were higher in Group IS and Group CS than those in Group CC. ConclusionsPostnatal normal diet may help most SGA female rats catch up their growth and normal pubertal development， while postnatal over-nutrition promotes precocious puberty in either SGA or AGA female rats.
