Ferroptosis： Novel Research Targets of Molecular Mechanism and Drug Therapy for Myocardial Ischemia-Reperfusion Injury

VernacularTitle:铁死亡：心肌缺血再灌注损伤分子机制和药物治疗研究新靶点
Author: Si-qi LIU ¹ ; Zheng-fei YANG ¹
Author Information

1. Department of Emergency， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510120， China
Publication Type:Review
Keywords: myocardial ischemia-reperfusion injury; ferroptosis; iron accumulation; lipid peroxidation
From: Journal of Sun Yat-sen University(Medical Sciences) 2022;43(5):712-719
CountryChina
Language:Chinese
Abstract: Myocardial ischemia-reperfusion injury （I/R） is an essential complication of reperfusion therapy， and it is also one of the significant causes of death in patients with cardiovascular disease and critical illness. Due to the complex pathogenesis， there is still a lack of effective prevention and treatment measures of myocardial I/R in clinical practice. Ferroptosis is a novel regulatory cell death found recently， which has become a research focus in the pathogenesis and therapeutic targets of many diseases. Studies have demonstrated a close association between myocardial I/R and ferroptosis. We reviewed the current research progress of ferroptosis in myocardial I/R， aiming to provide a new reference for preventing and treating myocardial I/R.