Significance of Serum Lipoprotein(a) in Patients with Acute Ischemic Stroke

VernacularTitle:急性缺血性脑卒中患者血清脂蛋白(a)水平及临床意义
Author: Shufen JIA ; Hongli LI
Publication Type:Journal Article
Keywords: stroke, acute, ischemia, lipoprotein(a), short-term, outcome
From: Chinese Journal of Rehabilitation Theory and Practice 2014;20(11):1063-1067
CountryChina
Language:Chinese
Abstract: Objective To investigate the serum lipoprotein (Lp) (a) level in patients with acute ischemic stroke and the prediction for short-term functional outcome. Methods The levels of serum Lp(a) were measured in 210 patients with acute ischemic stroke (within 24 h after onset) and 100 healthy people matched the gender and age. The patients were assessed with National Institutes of Health Stroke Scale (NIHSS) as admission, and modified Rankin Scale (mRS) as discharge. Results The median of Lp(a) was 325 mg/L (IQR: 180~545) in patients,significantly more than 148 mg/L (IQR: 69~265) in the normal controls (P<0.001). Level of serum Lp(a) was an independent variable for functional outcome (OR=1.004, 95%CI: 1.001~1.007, P<0.001) and death (OR=1.006, 95%CI: 1.001~1.008, P<0.001) in patients. In the receiver operating characteristic curve, the area under curve was more in the combined model [Lp(a) and NIHSS] than the NIHSS alone.Conclusion Serum Lp(a) increased in the in patients with acute ischemic stroke, and may predict the short-term outcome independently.