Advance in Relationship between Tau Protein and Alzheimer's Disease (review)
10.3969/j.issn.1006-9771.2014.11.009
- VernacularTitle:tau 蛋白与阿尔茨海默病的研究进展
- Author:
Jiangping HU
;
Rui GENG
;
Kaijun LI
- Publication Type:Journal Article
- Keywords:
Alzheime r's disease, tau protein, phosphorylation, neurofibrillary tangles, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2014;20(11):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease is a common neurodegenerative disease. One of the main pathology is neurofibrillary tangles in neurons,in which principal component is the phosphorylation of tau protein. Previous studies focused on senile plaques and Aβ levels. Recent studies indicated that the development of tau protein closely associated with Alzheimer's disease, especially the abnormal phosphorylation. This paper reviewed the relationship between tau protein phosphorylation and Alzheimer's disease based on the perspective of protein kinases and phosphatases.
