HIV subtypes in newly reported HIV-infected cases in Dehong Prefecture of Yunnan Province during 2017 to 2019

Xing Duan; Zhiyi Zhang; Jibao Wang; Runhua YE; Jin Yang; Sujuan Zhou; Yikui Wang; Tao Yang; Yuecheng Yang; Renhai Tang; Na HE; Yingying Ding; Song Duan

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HIV subtypes in newly reported HIV-infected cases in Dehong Prefecture of Yunnan Province during 2017 to 2019

VernacularTitle:云南德宏傣族景颇族自治州2017—2019年新报告HIV感染者基因亚型分布特征分析
Author: Xing DUAN ¹ ; Zhiyi ZHANG ² ; Jibao WANG ¹ ; Runhua YE ¹ ; Jin YANG ¹ ; Sujuan ZHOU ² ; Yikui WANG ¹ ; Tao YANG ¹ ; Yuecheng YANG ¹ ; Renhai TANG ¹ ; Na HE ² ; Yingying DING ² ; Song DUAN ¹
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1. Department of STD and AIDS Prevention， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， China
2. Department of Epidemiology， School of Public Health， Key Laboratory of Public Health Safety， Ministry of Education， Fudan University， Shanghai 200032， China
Publication Type:Journal Article
Keywords: HIV; HIV infector; gene subtype; recombinant gene subtype
From: Shanghai Journal of Preventive Medicine 2022;34(9):835-841
CountryChina
Language:Chinese
Abstract: ObjectiveTo determine the trend and influencing factors of HIV subtypes in newly reported HIV/AIDS cases in Dehong Dai and Jingpo Autonomous Prefecture （Dehong Prefecture） from 2017 to 2019. MethodsRNA extraction was conducted among newly reported HIV/AIDS cases in Dehong Prefecture from 2017 to 2019 whose plasma volume was more than 200 μL. The gag， env and pol genes were amplified by using RT-PCR and then sequenced to determine the subtypes. ResultsA total of 3 287 HIV-infected cases were newly reported in Dehong from 2017 to 2019. The HIV gag， env and pol genotypes were determined in 1 813 cases. The major subtypes were subtype C （28.4%，515/1 813）， recombination form BC （22.0%，398/1 813） and CRF_01AE （18.1%，329/1 813）. Furthermore， the proportion of subtype B， subtype C and CRF01_AE decreased over years， whereas 01/BC， CRF07_BC and CRF08_BC increased over years in both Chinese and Burmese patients （χ²=75.212，P<0.001）. There were significant differences in gender， age， marital status， ethnicity， educational level and transmission route among Chinese and Burmese HIV-infected cases with diverse HIV genotypes （all P<0.05）. ConclusionHIV subtypes in Dehong change over time， which demonstrates that the proportion of BC recombinant subtypes and unique recombinant subtypes increased significantly.