Association between Fetal Fraction of Cell-free DNA in Maternal Plasma and Adverse Pregnancy Outcomes
- VernacularTitle:孕妇外周血中游离胎儿DNA 浓度与不良妊娠结局的关系
- Author:
Xiao-yi BAI
1
;
Qiao-li FENG
1
;
Zhen-yan HAN
1
;
Hong-ying HOU
1
Author Information
1. Department of Obstetrics, the Third Affiliated Hospitalof Sun Yat-sen University, Guangzhou, 510630, China
- Publication Type:Journal Article
- Keywords:
fetal fraction of cell-free DNA;
hypertension disorders of pregnancy;
fetal growth restriction;
pretermbirth
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(6):917-923
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the association between fetal fraction(FF) of cell-free DNA and adverse pregnancy outcomes. 【Methods】 A retrospective case-control study was conducted in 1 231 Chinese pregnant women who underwent non-invasive prenatal testing and gave birth to their children in the Third Affiliated Hospital of Sun Yatsen University during January 2017 to October 2018, including HDP group(n = 84), FGR group(n = 57) and preterm birth group(n = 59) as case groups, and the pregnant women without pregnancy-related complications were included in the control group(n = 1 031). The correlation between FF and maternal age, gestational weeks, body mass index(BMI), and comparison of FF difference in different groups were analyzed. 【Results】 In 1 031 normal pregnant women performed NIPT, the plasma FF was(12.03 ± 3.64) %, FF and maternal BMI were negatively correlated(rs = -0.079, P < 0.05). FF in HDP, FGR, preterm birth group were(11.21 ± 2.60) %, (12.48 ± 3.92) %, (11.66 ± 3.34) % , respectively. Compared with control group, FF in HDP group was statistically lower, OR = 0.926, 95%CI: 0.859-0.997, P = 0.043. FF in FGR group and preterm birth group were not statistically different compared with control group. 【Conclusions】 Low FF is a risk factor of HDP, and we may apply FF of cell-free DNA to predict the risk of HDP in further research. The correlation of FF and FGR, preterm birth have not been found yet.
