Influence of Dyslipidemia during Pregnancy on Postpartum Glucose and Lipid Metabolism in GDM Patients
- VernacularTitle:妊娠期糖尿病患者孕期血脂水平对产后糖脂代谢的影响
- Author:
Huang-meng XIAO
1
;
Yan CHEN
1
;
Ling PEI
1
;
Ze-ting LI
1
;
Xiao-yu HUANG
1
;
Yan-bing LI
1
;
Haipeng XIAO
1
;
Xiao-pei CAO
1
Author Information
1. Endocrinology and Metabolism Department, The First Affiliated Hospital, SUN Yat-sen University, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
gestational diabetes mellitus;
gestational lipid level;
postpartum glycolipid metabolism
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(3):479-484
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the influence of dyslipidemia during pregnancy on postpartum glucose and lipid metabolism in gestational diabetes mellitus(GDM) patients. 【Methods】 A total of 416 GDM women were recruited. They were followed up and completed postpartum reexamination. According to the specific normal reference value of pregnant lipid level, those GDM women were divided into two groups: normal lipid group(n = 82) and dyslipidemia group (n = 334) .The general demographic data of 4-12 weeks after delivery were collected. OGTT, insulin and lipids level were measured, and the differences of postpartum glucose and lipid metabolism parameters between the two groups were compared. 【Results】 The abnormal rate of glucose metabolism in the early postpartum period of GDM women was 38.5%, and the incidence of dyslipidemia was 34.4%. The levels of postpartum TC, TG and LDL-c in the dyslipidemia group during pregnancy were significantly higher than those in the group with normal blood lipid during pregnancy, and the proportion of postpartum dyslipidemia in patients with high TG and high LDL-c during pregnancy was significantly higher. Correlation analysis showed that TG and HDL-c during pregnancy were positively correlated and negatively correlated with postpartum fasting blood glucose and HOMA-IR, respectively. 【Conclusion】 The dyslipidemia during pregnancy in patients with GDM is related to the disorder of glucose and lipid metabolism in the early postpartum period.
