Effect of Atorvastatin on Ventricular Remodeling and Expression of Cardiac AVP and TGF-β1
- VernacularTitle:阿托伐他汀对心室重塑和心肌AVP、TGF-β1 的影响
- Author:
Yuan-sheng ZHAI
1
;
Jie LI
2
,
3
;
Gui-hua LU
2
,
3
;
Qing-lang LI
2
,
3
;
Dong-mei XIE
2
,
3
;
Ju-hong ZHANG
2
,
3
;
Wei-yi MEI
1
;
Xiu-ren GAO
2
,
3
Author Information
1. Department of Cardiology, The Eastern Section of the First Affiliated Hospital, NHC Key Laboratory of Assisted Circulation, Guangzhou 510080, China
2. Department of Cardiology, The First Affiliated Hospital
3. Sun Yat-sen University, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
vasopressin;
atorvastatin;
ventricular remodeling;
TGF-β1
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(3):436-444
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the mechanism of atorvastatin improving ventricular remodeling in rats with myocardial infarction. 【Methods】 Ligation of left anterior descending coronary artery was performed to establish rat model of myocardial infarction. Thirty rats were divided into sham group(n=10), myocardial infarction group(n=10) and atorvastatin group(n=10). Echocardiography was used to examine cardiac function and left ventricular mass index(LVMI) was calculated. The content of arginine vasopressin(AVP) in left ventricular non-infarct area and serum was measured by ELISA. Masson staining was used to observed interstitial fibrosis of myocardium. Immunohistochemistry was used to measure the expression of type Ⅰ collagen. The protein expression of transforming growth factor-β1(TGF-β1) was detected by western blot. 【Results】 After 5 weeks, the number of rats in sham group, myocardial infarction group and atorvastatin group was 10, 9 and 10, respectively. Compared with sham group, LVEF was significantly decreased and, LVMI, interstitial fibrosis, the content of AVP, the expression of type Ⅰ collagen and TGF-β1 in the left ventricular non-infarct area were significantly increased in myocardial infarction group and atorvastatin group(P<0.05). Atorvastatin significantly increased LVEF and decreased interstitial fibrosis, the content of AVP, the expression of type Ⅰ collagen and TGF-β1 in the left ventricular non-infarct area(P<0.05) . 【Conclusion】 Atorvastatin could ameliorate ventricular remodeling in rats with myocardial infarction, which might be associated with inhibiting the expression of AVP and TGF-β1.
