Integrated medicinal chemistry: new modalities and methodologies in drug discovery
10.16438/j.0513-4870.2022-0947
- VernacularTitle:整合药物化学——药物发现中的新范式
- Author:
Shu-jing XU
;
Dang DING
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
new drug modality;
chemistry toolbox;
rug design;
medicinal chemistry;
smart design;
late-stage functionalization
- From:
Acta Pharmaceutica Sinica
2022;57(10):2889-2901
- CountryChina
- Language:Chinese
-
Abstract:
New drug research and development is a technology-intensive industry with high investment, high cycle and high risk. In recent years, with the rapid development of modern disciplines such as omics technology, bioinformatics, high-throughput and high-content screening, and artificial intelligence, the research and development of small-molecule drugs has presented a new paradigm characterized by "integrated medicinal chemistry". This review summarizes new enabling drug discovery technologies, the emergence of new subfields formed through integration innovations and practical chemistry toolbox in the field of medicinal chemistry.
