Research progress on the G protein modulators
10.16438/j.0513-4870.2022-0656
- VernacularTitle:G蛋白调节剂的研究进展
- Author:
Yi-fan YANG
;
Zhuo-rui HU
;
He LIU
;
Yi-xian LI
;
Lu LIU
;
Xiao-feng XIONG
- Publication Type:Research Article
- Keywords:
G protein;
isease;
modulator;
inhibitor
- From:
Acta Pharmaceutica Sinica
2022;57(10):2921-2931
- CountryChina
- Language:Chinese
-
Abstract:
Heterotrimeric G proteins are classes of signal-transducing proteins that bind to guanine nucleotides and possess GTP hydrolase activity. G proteins are composed of three subunits α, β, and γ, and are considered as the "molecular switch" in the GPCR signaling pathway. The abnormal activation of G protein is strongly related to diseases such as uveal melanoma, asthma, et al., making directly targeting G protein as an promising strategy for combating diseases. In this review, the classification and physiological functions of G protein are briefly described, and the research progress of G proteins in diseases, G protein modulators are reviewed.
