Research progress of leukotriene B<sub>4</sub> receptor antagonists

VernacularTitle:白三烯B₄受体拮抗剂的研究进展
Author: Tian-tian ZHAO ; Long-ying SHEN ; Xian-dao PAN
Publication Type:Research Article
Keywords: leukotriene B₄; antagonist; structure-activity relationship
From: Acta Pharmaceutica Sinica 2022;57(10):3133-3145
CountryChina
Language:Chinese
Abstract: Leukotriene B₄ (LTB₄) is a proinflammatory lipid mediator that is synthesized by a number of inflammatory cells. Binding of LTB₄ to its receptor leukotriene B₄ receptor 1 (BLT1) can migrate neutrophils and macrophages to inflammatory sites through chemotaxis and up-regulation of adhesion molecules. Many researches have shown that LTB₄-BLT1 axis is related to the occurrence of autoimmune disorders and other inflammatory diseases. Receptor antagonists of LTB₄ are thus expected to be useful therapeutics for these diseases. In this review, we briefly describe the biological function of LTB₄ and summarize the preclinical and clinical developments of LTB₄ receptor antagonists.