Research progress on pharmacological effects and clinical combined application of 3-n-butylphthalide in cerebrovascular diseases
10.16438/j.0513-4870.2022-0366
- VernacularTitle:丁基苯酞在脑血管病的药理作用及临床联合应用的研究进展
- Author:
Wen-juan NI
1
;
Wei-xia LI
2
;
Xiao-yan WANG
2
;
Ya-li WU
2
;
Bing HAN
1
;
Jin-hao JIA
1
;
Kun LI
1
;
Qiu-ru JI
1
;
Jin-fa TANG
2
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450046, China
2. Henan Province Engineering Research Center of Clinical Application, Evaluation and Transformation of Traditional Chinese Medicine, Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Research Article
- Keywords:
3-n-butylphthalide;
cerebrovascular disease;
pharmacological action;
clinical combined application
- From:
Acta Pharmaceutica Sinica
2022;57(10):3047-3056
- CountryChina
- Language:Chinese
-
Abstract:
Cerebrovascular diseases have the characteristics of high morbidity, high disability, high mortality and high recurrence rate, which seriously harm human health and increase the national health economic burden. 3-n-Butylphthalide (NBP) is a new drug commonly used in clinical treatment of cerebrovascular diseases, and it is also one of the main active components in traditional Chinese medicine such as Angelica sinensis and Chuanxiong. In this review, the pharmacological effects of NBP were systematically summarized. Studies have shown that NBP has pharmacological effects such as antiplatelet aggregation, anti-thrombosis, inhibiting neuronal apoptosis, anti-oxidation, anti-cerebral ischemia, anti-brain injury, and anti-vascular dementia. In clinical practice, it is often combined with edaravone, alteplase, fasudil, Xingnaojing injection, and compound Danshen injection to treat cerebral vascular diseases such as stroke, vascular dementia, and cerebral vasospasm, and plays a good synergistic effect. This summary could provide support for the rational clinical application of NBP, and also provide basis for the in-depth study of the interaction of its drug combination.
