Research progress of transcatheter aortic valve replacement in patients with coexisting moderate to severe mitral regurgitation
- VernacularTitle:合并中重度二尖瓣反流患者行经导管主动脉瓣置换术的研究进展
- Author:
Peijian WEI
1
,
2
,
3
;
Tong TAN
1
,
2
,
3
;
Hongxiang WU
2
,
4
;
Jian LIU
2
,
4
;
Huiming GUO
2
,
4
Author Information
1. 1.Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong People&rsquo
2. s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, P. R. China
3. 2. Shantou University Medical College, Shantou, 515041, Guangdong, P. R. China
4. Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong People&rsquo
- Publication Type:Journal Article
- Keywords:
Transcatheter aortic valve replacement;
moderate to severe mitral regurgitation;
transcatheter edge-to-edge repair;
mixed valvular diseases
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(08):1060-1065
- CountryChina
- Language:Chinese
-
Abstract:
After nearly two decades of application and development, the clinical efficacy of transcatheter aortic valve replacement (TAVR) has been continuously improved and demonstrated. Due to the expansion of indications of TAVR, the frequency of encountering patients with mixed valvular diseases increases greatly, particularly the moderate to severe mitral regurgitation combined with aortic stenosis. Multiple registry studies suggest that the incidence of significant mitral regurgitation is approximately 13% to 74% in patients who undergo TAVR. Some studies have reported that moderate to severe MR is associated with higher mortality, while simultaneous aortic and mitral valve surgery is associated with significantly higher surgical risk. Therefore, the optimal treatment strategy for this special patient group remains uncertain. With the further development of transcatheter therapy, staged surgery may be a feasible solution. However, there is currently a lack of evidence-based support such as randomized clinical trials. This review aims to report and evaluate relevant existing research data to help clinicians make optimal treatment decisions for this specific patient populations.
