Clinical effect of transcatheter aortic valve replacement on severe aortic regurgitation combined with severe mitral regurgitation: A single-center retrospective study

Hongxiang WU; Tong Tan; Peijian Wei; Yanjun Liu; Xiaoyi LI; Wei Zhu; Huanlei Huang; Jian Liu; Huiming Guo; Jimei Chen; Jian Zhuang

Return

Clinical effect of transcatheter aortic valve replacement on severe aortic regurgitation combined with severe mitral regurgitation: A single-center retrospective study

VernacularTitle:单纯经导管主动脉瓣置换术治疗重度主动脉瓣反流合并重度二尖瓣反流的单中心回顾性研究
Author: Hongxiang WU ^{1
,

2} ; Tong TAN ^{2
,

3
,

4} ; Peijian WEI ^{2
,

3
,

4} ; Yanjun LIU ^{1
,

2} ; Xiaoyi LI ^{1
,

2} ; Wei ZHU ^{1
,

2} ; Huanlei HUANG ^{1
,

2} ; Jian LIU ^{1
,

2} ; Huiming GUO ^{1
,

2} ; Jimei CHEN ^{1
,

2} ; Jian ZHUANG ^{1
,

2}
Author Information

1. Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People'
2. s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, P. R. China
3. 1.Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People'
4. 2. Shantou University Medical College, Shantou, 515041, Guangdong, P. R. China
Publication Type:Journal Article
Keywords: Transcatheter aortic valve replacement; severe mitral regurgitation; functional mitral regurgitation; severe aortic regurgitation
From: Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2022;29(08):971-976
CountryChina
Language:Chinese
Abstract: Objective To determine the clinical efficacy of transcatheter aortic valve replacement (TAVR) for severe aortic regurgitation (AR) combined with severe mitral regurgitation (MR). Methods The clinical data of 13 patients who underwent TAVR due to severe AR combined with severe MR from March 2018 to September 2021 in our hospital were retrospectively analyzed, including 10 males and 3 females with a mean age of 72.54±2.35 years. The echocardiographic findings of all patients were compared preoperatively and postoperatively. Results Surgeries were performed successfully in all patients without intraoperative death or conversion to sternotomy. The operation time was 118.15±11.42 min, intraoperative blood loss was 100.00 (75.00, 250.00) mL, and the length of hospital stay after surgery was 9.00 (4.50, 11.00) d. The mean follow-up duration was 10.00 (6.50, 38.50) months, during which there were 2 patients with mild to moderate AR, 6 with mild AR, and 5 with no AR; meanwhile, severe MR decreased significantly (P=0.001) even without active intervention, including 4 mild to moderate MR and 9 mild MR patients. Compared to preoperative indexes, the left atrial diameter [46.00 (41.00, 52.50) mm vs. 35.00 (34.00, 41.00) mm, P<0.001], left ventricular end-systolic diameter [45.00 (36.00, 56.00) mm vs. 35.00 (28.00, 39.00) mm, P=0.002] and left ventricular end-diastolic diameter (62.62±2.40 mm vs. 51.08±2.49 mm, P<0.001) showed a decreasing trend during the follow-up. Conclusion In selected patients with severe AR combined with severe MR, TAVR alone improves AR and combined MR at the same time.