Recent advancement in research on intrahepatic cholangiocarcinoma: Risk factors and pathogenesis
10.3969/j.issn.1001-5256.2022.10.037
- VernacularTitle:肝内胆管癌的危险因素与发病机制
- Author:
Yu LIANG
1
;
Yuanhong ZHAO
1
;
Zheng LI
2
Author Information
1. Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
2. Department of Pharmaceutical Preparations, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
- Publication Type:Reviews
- Keywords:
Bile Duct Neoplasms;
Risk Factors;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(10):2391-2395
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholangiocarcinoma (ICC) accounts for the second highest hepatobiliary malignancy after hepatocellular carcinoma. ICC has a complex etiology and is a high invasive disease with a poor prognosis. To date, surgical resection is still the best treatment to cure early staged ICCs clinically; however, due to ICC diagnosis at the advanced stages of disease and tumor with high degree of malignancy, most patients miss the optimal time for surgery. Thus, it is crucial to detect and intervene ICC at the earliest stage of disease clinically. The ICC risk factors may include primary sclerosing cholangitis, viral hepatitis, and intrahepatic cholangiolithiasis. The rapid development of molecular biology and genetics provides a better methodology in in-depth study of ICC pathogenesis. This review summarized and discussed the most recent advancement in identification of the ICC risk factors and molecular mechanisms of ICC pathogenesis, which may provide valuable and insightful information for ICC early detection and potential treatment strategy.
