Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis
10.3969/j.issn.1001-5256.2022.10.033
- VernacularTitle:肝纤维化发生机制及其中药逆转治疗的研究进展
- Author:
Shiheng LIU
1
;
Suxian ZHAO
1
;
Yuguo ZHANG
1
Author Information
1. Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang 050000, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Hepatic Stellate Cells;
Drugs, Chinese Herbal
- From:
Journal of Clinical Hepatology
2022;38(10):2373-2377
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis occurs due to damages caused by liver diseases of various etiologies and activation of hepatic stellate cells, leading to the repairing and damaging cycle by secreting a large amount of extracellular matrix and formation of fibrosis tissues in the liver. Early reversal of this process could prevent further development and progression of the disease, which may reduce incidence of the end-stage liver disease and even liver cancer. This review summarized and discussed recent advancements and mechanisms of liver sinusoidal endothelial cells, Notch signaling pathway, YAP/TAZ signaling pathway, and autophagy in regulation of liver fibrosis and then enumerated the Traditional Chinese Medicine in reversal of liver fibrosis process and the underlying molecular mechanisms. It expects to provide novel approaches and research ideas for future control of liver fibrosis using Traditional Chinese Medicine.
