Role of bile acid metabolism in the pathogenesis of primary biliary cholangitis
10.3969/j.issn.1001-5256.2022.10.031
- VernacularTitle:胆汁酸代谢在原发性胆汁性胆管炎发病机制中的作用
- Author:
Wanting JIA
1
;
Xiaoxiao LIU
1
;
Wenlin TAI
1
Author Information
1. Department of Clinical Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Reviews
- Keywords:
Primary Biliary Cholangitis;
Bile Acids and Salts;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(10):2362-2367
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by a high incidence rate in middle-aged and elderly women, lymphocyte infiltration in small bile ducts, and cholestasis. Main clinical manifestations include fatigue and pruritus caused by cholestasis. Ursodeoxycholic acid and obeticholic acid are currently approved therapeutic drugs for PBC and exert a therapeutic effect by regulating bile acid metabolism and specifically and effectively improving cholestasis. This article introduces the physiological and pathological changes of bile acids in disease states and summarizes the possible ways in which bile acid metabolism is involved in the pathogenesis of diseases and the current treatment methods for bile acid metabolism. It is pointed out that the changes of bile acid metabolism in PBC are mainly associated with anion exchanger 2 deficiency, innate genetic variation and acquired adaptive changes of bile acid metabolism transporters and nuclear receptors, and changes in the structure of intestinal flora.
