Association between the sirtuin family of deacetylases and nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2022.10.030
- VernacularTitle:去乙酰化酶Sirtuins家族与非酒精性脂肪性肝病的关系
- Author:
Yekai ZONG
1
;
Jiangkai LIU
2
Author Information
1. The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450008, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450008, China
- Publication Type:Reviews
- Keywords:
Non-alcoholic Fatty Liver Disease;
Sirtuins;
Deacetylation
- From:
Journal of Clinical Hepatology
2022;38(10):2357-2361
- CountryChina
- Language:Chinese
-
Abstract:
The sirtuin family of deacetylases widely exists in human cells and can regulate the post-translational chemical modification of various proteins by acting on mitochondria, endoplasmic reticulum and nucleus, thereby influencing the process of biological metabolism. The sirtuin family is also involved in a variety of pathophysiological reactions in nonalcoholic fatty liver disease (NAFLD). This article reviews the research advances in the association between the sirtuin family of deacetylases and nonalcoholic fatty liver disease, so as to provide a potential approach for NAFLD treatment in the future.
