The discussion on the Genetically Modified Pigs for the treatment of acute liver failure
10.3969/j.issn.1001-5256.2022.10.004
- VernacularTitle:基因编辑猪用于急性肝衰竭治疗的路径探讨
- Author:
Guoli HUAI
1
;
Jiaxiang DU
2
;
Dengke PAN
1
Author Information
1. Affiliated Hospital of University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Sichuan Key Laboratory of Clinical Immunological Translational Medicine, Chengdu 610072, China
2. Chengdu Sino-Clone Organ Biotechnology, Co., Ltd., Chengdu 610094, China
- Publication Type:Discussions by Experts
- Keywords:
Liver Transplantation;
Gene Editing;
Chimera;
Swine
- From:
Journal of Clinical Hepatology
2022;38(10):2214-2218
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplants are in huge demand in China, but facing the problem of extreme shortage of donor organs. Xenogeneic (pig) liver transplantation may be a potential way to alleviate the shortage of donors. The liver is a detoxifying organ with synthetic functions, and when genetically modified pigs are used as donors, it faces the dual problem of overcoming immune rejection and resolving physiological function mismatches. Therefore, suppressing the innate immune response can better alleviate the immune rejection of xenotransplantation. In addition, the use of chimeras of humanized cell livers may resolve the problem of physiological function mismatch. Moreover, with the development of gene editing technology, it has become possible to obtain multiple gene edited pigs and chimeras. Therefore, exploring and researching from these two aspects will hopefully solve the current problems of liver xenotransplantation and promote the further development of the field of liver xenotransplantation.
