Research progress on biomarkers of coal workers′ pneumoconiosis
10. 20001/j. issn. 2095⁃2619. 20224020
- Author:
li baolin
;
yuan baojun
- Publication Type:Journal Article
- Keywords:
Coal workers' pneumoconiosis；Biomarkers；Inflammation；Alveolar epithelial cell；Epigenetics；Immune dysfunction
- From:
China Occupational Medicine
2022;49(2):228-233
- CountryChina
- Language:Chinese
-
Abstract:
Coal workers' pneumoconiosis（CWP）is one of the most common occupational diseases. The pathogenesis of CWP
remains unclear and effective therapeutic drug is not exist. Therefore，looking for CWP-related biomarkers have become a focus
of research. In recent years，intensive studies have been carried out on the pathogenesis of CWP，such as inflammatory
response，alveolar epithelial cell injury，extracellular matrix remodeling，epigenetics，oxidative stress and immune dysfunction.
It has been found that some biomarkers were related to CWP，such as high mobility group protein 1，nucleotide-binding
oligomerization domain-like receptor family protein 3，surfactant protein，mucoprotein 5B，osteopontin，aminin，DNA
methylation，microRNA，long noncoding RNA，cytochrome b-245-alpha polypeptide and cluster of differentiation，and others.
These biomarkers are helpful for early screening，monitoring efficacy and pathogenesis research of CWP. However，it is
necessary to further explore biomarkers with high sensitivity and specificity and conduct prospective clinical value evaluation to
better guide the prevention and treatment of CWP .
