Research progress on lung cancer caused by welding fumes
- Author:
xu xiaoli
- Publication Type:Journal Article
- Keywords:
Welding fumes；Lung cancer；Occupational epidemiology；Animal experiments；Mechanism of carcinogenesis
- From:
China Occupational Medicine
2022;49(2):222-227
- CountryChina
- Language:Chinese
-
Abstract:
Welding fumes exposure increased the risk of lung cancer. The factors that cause lung cancer included：welding fume
of chromium，nickel and their compounds，smoking and asbestos dust，welding types and welding materials. The results of
animal experiments showed that the metal compounds in welding fumes could be deposited in lung tissue and caused persistent
mild inflammation which led to increase lung tumor in animal models. Chromium，nickel，iron compounds could cause tumor
separately. The use of tumor initiator pretreatment led to increase the number of lung tumor with statistical significance. The
mechanisms of lung cancer development include chronic inflammation that caused by continuous deposition of carcinogenic
metal oxides such as chromium and nickel in the lung. Free radicals peroxidation causes DNA damage，which acts on tumor
related
genes and causes their abnormal expression and generates lung tumor cells. Activating telomerase activity may promote
normal cells transform into immortalized tumor cells. By activating nuclear factor erythroid 2-related factor-2 and nuclear factor
Kappa B signaling，welding fumes cause inflammation，DNA damage and formation of lung tumor cells. Welding fumes also
intervenes immune modulatory system and leads to tumor cell formation.
Keywords: Welding fumes；Lung cancer；Occupational epidemiology；Anim
