Expression of EphrinB2 Signal in Cerebral Cortex in Ischemic Stroke Rats

VernacularTitle:缺血性脑卒中大鼠大脑皮层EphrinB2 信号表达变化的研究
Author: Xinlei GUO ; Fangling SUN ; Houxi AI ; Li ZHANG ; Wen WANG ; Yi AN
Publication Type:Journal Article
Keywords: stroke, middle cerebral artery occlusion, ischemia/reperfusion, EphrinB2, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2014;(2):129-132
CountryChina
Language:Chinese
Abstract: Objective To observe the expression of phosphorylated EphrinB2 in brain after focal cerebral ischemia/reperfusion in rats.Methods 24 male Sprague-Dawley rats were randomly divided into sham group (n=12) and model group (n=12). The model group was modeled as middle cerebral artery occlusion and reperfusion with nylon monofilament suture, and then was assessed with Longa's score. The expression of phosphorylated EphrinB2 in cerebral cortex was detected with immunohistochemistry and Western blotting. Results The expression of phosphorylated EphrinB2 and the number of positive cells were significantly higher in the sham group than in the control group (P<0.05). It existed in the vascular endothelium in cerebral cortex. Conclusion EphrinB2 signaling pathway is activated in ischemic stroke.