Risk factors for tigecycline -induced hypofibrinogenaemia ：a systematic review
- VernacularTitle:替加环素致低纤维蛋白原血症的危险因素的系统评价
- Author:
Yupei HAO
1
;
Jing SUN
2
;
Chunhua ZHOU
1
;
Lingjiao WANG
1
;
Jing WANG
1
;
Yan LIU
1
;
Jing YU
1
Author Information
1. Dept. of Clinical Pharmacy，Hebei Medical University，Shijiazhuang 050031，China
2. School of Pharmacy，Hebei Medical University，Shijiazhuang 050031，China
- Publication Type:Journal Article
- Keywords:
tigecycline;
hypofibrinogenaemia;
risk factors;
meta-analysis
- From:
China Pharmacy
2022;33(19):2404-2408
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the risk factors for tigecycline -induced hypofibrinogenaemia by systematic review . METHODS The literature about risk factors for tigecycline -induced hypofibrinogenaemia were retrieved from English databases （PubMed，Cochrane Library ，Embase，Web of Science ）and Chinese databases （CNKI，Wanfang Database ，VIP，CBM）during the inception to Feb . 5th，2022. At the same time ，the unpublished clinical trial data were additionally searched . After the quality evaluation of the included literature was carried out by adopting the Castle -Ottawa Scale （NOS），data were extracted from the literature that met the inclusion criteria ，and Meta -analysis was conducted by using RevMan 5.3 software. RESULTS Finally，8 literature were selected ，with a total of 1 374 cases，including 706 cases in the trial group and 668 cases in the control group . There were 4 Chinese and 4 English literature ，all of which were case control studies published between 2017-2021. Meta-analysis showed that the risk factors for tigecycline -induced hypofibrinogenaemia were age [OR＝1.04，95%CI（1.02，1.06），P＝0.000 5]，baseline fibrinogen level [OR＝0.54，95%CI（0.42，0.69），P＜0.000 01]，abdominal infection （sensitivity analysis ）[OR＝9.43，95%CI（4.24， 20.95），P＜0.000 01]，dose each time [OR＝2.87，95%CI（2.04，4.02），P＜0.000 01]，medication time [OR＝1.10，95%CI（1.00， 1.22），P＝0.04]. CONCLUSIONS Advanced age ，low baseline fibrinogen levels ，abdominal cavity infection ，relative high dose each time and slightly long medication time are potential risk factors for tigecycline -induced hypofibrinogenaemia . If the above risk factors exist ，it is suggested to pay close attention to the occurrence of hypofibrinogenaemia in the course of tigecycline administration.
